Human umbilical cord platelet-rich plasma to treat endometrial pathologies: methodology, composition and pre-clinical models

人脐带富血小板血浆治疗子宫内膜病变:方法学、成分和临床前模型

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作者:Adolfo Rodríguez-Eguren, Lucía de Miguel-Gómez, Emilio Francés-Herrero, María Gómez-Álvarez, Amparo Faus, Macarena Gómez-Cerdá, Inés Moret-Tatay, Ana Díaz, Antonio Pellicer, Irene Cervelló

Methods

Umbilical cord blood was obtained from women in childbirth. Endometrial damage (mimicking AS/EA) was induced using ethanol in 8-week-old C57BL/6 mice, and treated with the most concentrated hUC-PRP sample 4 days later. Characterization of hUC-PRP and immunotolerance was carried out with multiplex technology, while uterine samples were analyzed by immunohistochemistry and quantitative PCR. The number of embryos and their morphology was determined visually. Main

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