How We Came to Understand the "Tumultuous Chemical Heterogeneity" of the Lipid Bilayer Membrane

我们是如何理解脂质双层膜“复杂的化学异质性”的

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Abstract

The path to our modern understanding of the structure of the lipid bilayer membrane is a long one that can be traced from today perhaps as far back as Benjamin Franklin in the eighteenth century. Here, I provide a personal account of one of the important steps in that path, the description of the "Complete Structure" of a hydrated, fluid phase dioleoyl phosphatidylcholine bilayer by the joint refinement of neutron and X-ray diffraction data by Stephen White and his colleagues.

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