Background
Dietary supplements targeting fat loss and increased thermogenesis are prevalent within the sport nutrition/weight loss market. While some isolated ingredients have been reported to be efficacious when used at high dosages, in particular in animal models and/or via intravenous delivery, little
Conclusion
The dietary supplement results in an acute increase in plasma NE and markers of lipolysis, as well as metabolic rate. This occurs without altering hemodynamic variables in a clinically significant manner. Intervention studies to determine the impact of this dietary supplement on weight/fat loss are warranted.
Methods
Ten resistance trained men (age = 27 +/- 4 yrs; BMI = 25 +/- 3 kg. m-2; body fat = 9 +/- 3%; mean +/- SD) ingested a dietary supplement (Meltdown(R), Vital Pharmaceuticals) or a placebo, in a random order, double blind cross-over design, with one week separating conditions. Fasting blood samples were collected before, and at 30, 60, and 90 minutes post ingestion and were assayed for epinephrine (EPI), norepinephrine (NE), glycerol, and free fatty acids (FFA). Area under the curve (AUC) was calculated for all variables. Gas samples were collected from 30-60 minutes post ingestion for measurement of metabolic rate. Heart rate and blood pressure were recorded at all blood collection times.
Results
AUC was greater for the dietary supplement compared to the placebo for NE (1332 +/- 128 pg.mL-1.90 min-1 vs. 1003 +/- 133 pg.mL-1.90 min-1; p = 0.03), glycerol (44 +/- 3 mug.mL-1.90 min-1 vs. 26 +/- 2 mug.mL-1.90 min-1; p < 0.0001), and FFA (1.24 +/- 0.17 mmol.L-1.90 min-1 vs. 0.88 +/- 0.12 mmol.L-1.90 min-1; p = 0.0003). No difference between conditions was noted for EPI AUC (p > 0.05). For all variables, values were highest at 90 minutes post ingestion. Total kilocalorie expenditure during the 30 minute collection period was 29.6% greater (p = 0.02) for the dietary supplement (35 +/- 3 kcal) compared to placebo (27 +/- 2 kcal). A condition main effect was noted for systolic blood pressure (p = 0.04), with values increasing from 117 +/- 2 mmHg to 123 +/- 2 mmHg with the dietary supplement, while remaining unchanged for placebo. No other hemodynamic changes were noted (p > 0.05).