Conclusion
Increasing in the number of branches and the size of interior voids and number of conjugated β-CDs cause to enhance the loading capacity.
Methods
To achieve β-CD-modified dendrimers, first citric acid dendrimers were synthesized and then the end functional groups of dendrimers were grafted to β-CD through ester linkages. The molecular structures of resulted dendrimers were verified using common spectroscopic methods such as 1H NMR, FT-IR and the diameters of obtained nanocarriers were evaluated with using dynamic light scattering (DLS) experiments. The isolated dendrimers were utilized as the drug delivery agents and the encapsulation and the controlled release of guest drug molecule Naltrexone (NLX) was investigated in different pH's using UV spectroscopy method.
Results
It was established that the loading capacity of dendrimers depend on several factors such as their generation and the structure and number of conjugated modifier end groups.