Abstract
Learning changes the activity of neurons across multiple brain regions, but the significance of this distributed organization remains poorly understood, owing in part to the difficulty of observing brain-wide activity patterns in commonly used mammalian model systems. This review discusses the promise of using the small and optically accessible nervous system of larval zebrafish to study the brain-wide networks that encode experience. I discuss the opportunities and challenges of studying learning and memory in the larval zebrafish, the lessons learned from recent studies of brain-wide imaging during experience-dependent behavior, and the potential for using zebrafish neurotechnology to understand the physiological principles and behavioral significance of distributed memory networks.