Organophotoredox Dioxygenation of Alkenes via ROH···F-Activated N-Alkoxyphthalimides

通过 ROH···F 活化的 N-烷氧基邻苯二甲酰亚胺对烯烃进行有机光氧化还原双加氧反应

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Abstract

The generation and controlled reactivity of alkoxyl radicals remain challenging due to their high energy and tendency for β-scission or hydrogen atom transfer events. Herein, we report a photoredox-catalyzed dioxygenation of alkenes enabled by the activation of fluorinated N-alkoxyphthalimides through hydrogen-bonded aggregates with ROH···F. This transformation proceeds under mild, metal-free conditions using an organophotocatalyst and a simple alcohol, affording a diverse range of dialkoxylated products with high functional group tolerance and good scalability. Mechanistic studies─including UV-Vis spectroscopy, NMR, cyclic voltammetry, and Stern-Volmer quenching─reveal a radical/polar crossover pathway.

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