Nickel-Catalyzed Carbonylative Cyclization of Bromodifluoroacetamides with Arylboronic Acids toward δ-Lactams

A nickel-catalyzed radical cyclization/carbonylation reaction of bromodifluoroacetamides with arylboronic acids has been explored. This strategy allows for the synthesis of δ-lactams bearing both gem-difluoro and carbonyl groups through a sequential single-electron transfer, 6-exo-trig cyclization, and carbonyl insertion process. This method proceeds under mild reaction conditions with good functional group compatibility, enabling the preparation of various structurally diverse δ-lactams that might have further applications in medicinal chemistry.