The Baeyer-Villiger Oxidation of Cubyl Ketones: A Synthetic Route to Functionalized Cubanols

立方酮的拜耳-维利格氧化反应:功能化立方醇的合成路线

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Abstract

The synthesis of functionalized cubanols has been developed via a 2-step protocol comprising of a Baeyer-Villiger oxidation of cubyl ketones, followed by acid hydrolysis. As part of this study, we determine the relative migratory aptitude of cubyl groups in the Baeyer-Villiger oxidation and rationalize these experimental findings with computational studies.

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