Bromination Functionalization of Diazo Compounds with CBr(4) via Convergent Paired Electrolysis

利用汇聚式配对电解法,以CBr(4)对重氮化合物进行溴化官能化

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Abstract

An electrochemical bromination of diazo compounds with CBr(4) as a bromine source via convergent paired electrolysis has been developed, which affords α-bromo phosphonates as products in up to 96% yields. This work represents the first example of direct anodic oxidation of diazos to couple with an in situ-generated nucleophile from the cationic reduction of CBr(4) by using CH(2)Cl(2) as a hydrogen source. This reaction features mild conditions, good substrate compatibility, and scale-up applicability, which represents a new electrochemical reaction mode of diazo compounds and also provides easy access to α-bromo phosphonates.

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