Abstract
In an effort to expand the availability of simple polysulfides for H(2)S donation, we report here the synthesis and H(2)S release profiles of bis(aryl) and bis(alkyl) tetrasulfides. The tetrasulfide donors release H(2)S in a first-order dependence on reduced glutathione (GSH) and release more H(2)S than the commonly used trisulfide DATS.