Formal (4 + 1)-Addition of Allenoates to o-Quinone Methides

烯丙酸酯与邻醌甲醚的正式 (4 + 1) 加成

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Abstract

The first (4 + 1)-annulation of o-quinone methides with α-branched allenoates as C1 synthons has been developed. This operationally simple protocol gives access to highly functionalized dihydrobenzofurans in an unprecedented fashion with excellent diastereoselectivities and high yields.

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