Synthesis of the ABC- and D-ring systems of the indole alkaloid ambiguine G

吲哚生物碱ambiguine G的ABC环和D环体系的合成

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Abstract

A glycine Schiff base Michael addition is used in sequence with free radical-mediated aryl amination to ultimately arrive at the ambiguine G ABC-tricycle convergently. Additionally, thermal Diels-Alder cycloaddition of beta-chloromethacrolein with Cohen's diene is used to diastereoselectively construct the D-cyclohexane ring bearing a neopentyl chloride.

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