Recent advances in bioprinting technologies for engineering cardiac tissue

心脏组织工程生物打印技术的最新进展

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作者:Tarun Agarwal, Gabriele Maria Fortunato, Sung Yun Hann, Bugra Ayan, Kiran Yellappa Vajanthri, Dario Presutti, Haitao Cui, Alex H P Chan, Marco Costantini, Valentina Onesto, Concetta Di Natale, Ngan F Huang, Pooyan Makvandi, Majid Shabani, Tapas Kumar Maiti, Lijie Grace Zhang, Carmelo De Maria3

Abstract

Annually increasing incidence of cardiac-related disorders and cardiac tissue's minimal regenerative capacity have motivated the researchers to explore effective therapeutic strategies. In the recent years, bioprinting technologies have witnessed a great wave of enthusiasm and have undergone steady advancements over a short period, opening the possibilities for recreating engineered functional cardiac tissue models for regenerative and diagnostic applications. With this perspective, the current review delineates recent developments in the sphere of engineered cardiac tissue fabrication, using traditional and advanced bioprinting strategies. The review also highlights different printing ink formulations, available cellular opportunities, and aspects of personalized medicines in the context of cardiac tissue engineering and bioprinting. On a concluding note, current challenges and prospects for further advancements are also discussed.

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