Prolonged Fever and Severe Hypercalcemia Revealing Systemic Extrapulmonary Sarcoidosis: A Lesson to be Learned

持续发热和严重高钙血症提示系统性肺外结节病:值得吸取的教训

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Abstract

Sarcoidosis often manifests with pulmonary involvement, making isolated extrapulmonary presentations rare and diagnostically challenging. We present the case of a 43-year-old woman who presented with prolonged fever, deep lymphadenopathy, massive splenomegaly, hepatomegaly, and severe hypercalcemia, mimicking malignancy. The diagnosis of sarcoidosis was established after the failure of anti-tubercular therapy, exclusion of differential diagnosis, and the subsequent development of cutaneous sarcoids. This case highlights the importance of recognizing isolated extrapulmonary pseudo-tumoral presentations of sarcoidosis, which can lead to delayed diagnosis.

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