Abstract
This case report describes the successful laparoscopic radical nephrectomy in a 69-year-old woman with situs inversus totalis and a large, hypervascular left renal mass. Despite the presence of metastatic disease, the patient underwent neoadjuvant immunotherapy followed by surgery. The successful laparoscopic approach highlights the feasibility of minimally invasive surgery even in patients with complex anatomical variations. This report provides valuable insights into the surgical management of renal tumors in individuals with situs inversus totalis.