Abstract
BACKGROUND: Amyloidosis of the bladder is a benign condition which can present with a multitude of symptoms including bladder mass, irritative voiding symptoms and haematuria. CASE PRESENTATION: We report on the investigation and management of a patient with recurrent localised amyloidosis of the bladder, which appears to have been managed fortuitously by concurrent methotrexate prescribed for another indication. CONCLUSION: We provide further assessment and management with a focus on the possible benefit of methotrexate for management of localised bladder amyloidosis.