Abstract
Substance use and abuse in adolescents is a major public health concern in India where a high proportion of the population are in this age group. The most common substances used by adolescents are tobacco, alcohol, and marijuana, but include a wider range of substances. Two patients with polysubstance abuse are presented. After initial detoxification, both were started with dialectical behavioral therapy and motivational enhancement therapy along with family therapy; both have been on regular follow-up and currently maintaining well.