Abstract
Chromosomal rearrangements are believed to play a critical role in shaping the eco-evolutionary dynamics of diverse organisms, including mosquitoes. The availability of high-quality genome assemblies of multiple mosquito species has revolutionized the study of these rearrangements. Researchers can now employ genomic approaches to identify chromosomal rearrangements and gain new insights into their role in both microevolutionary and macroevolutionary processes. Autosomal inversions are emerging as possible key drivers of adaptation in mosquitoes. By maintaining standing genetic variation, inversions enable mosquito populations to rapidly adapt to environmental pressures, including insecticide-based vector control methods. X-chromosomal inversions may also play a role in speciation by reducing gene flow between diverging populations. Since mosquitoes are primary vectors of many human diseases, understanding the genomic basis of their adaptation and evolution is important from an epidemiological perspective. Studying chromosomal rearrangements can help identify chromosomal regions associated with adaptation to environmental stresses or insecticide resistance, thereby improving the efficacy of disease management programs.