Immunohistochemical expression of interleukin-17 and hormonal receptors in benign and malignant breast lesions

乳腺良、恶性病变中白细胞介素-17及激素受体的免疫组织化学表达

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作者:Eman Taha Ali, Mai Abdulrahman Mohammed Masri, Emmanuel Edwar Siddig, Ayman Ahmed, Mohamed S Muneer, Nouh Saad Mohamed, Ali Mahmoud Mohammed Edris

Results

A total of 137 cases of breast lesions were studied, 97 (70.8%) were malignant and 40 (29.2%) were benign cases. Age range for malignant and benign cases were between 26 and 80 years [mean age 50 ± 2 years], and 20 to 70 years [mean age 41 ± 4 years], respectively, Odds ratio = 2.3 [1.78-1.99, 95% CI]. The majority of the histopathological diagnosis of the benign and malignant lesions were 21 (15.3%) fibro-adenomas and 87 (63.5%) invasive ductal carcinoma, respectively. Expression of IL17 and age were insignificantly negatively correlated for both groups; benign cases [r = - 0.054, P value 0.742] and malignant cases [r = - 0.080, P value 0.444]. IL17 expression was showing insignificant association with age group, P value 0.065. IL17 expression showed a statistical significance based on the different histopathological diagnosis, P value 0.035. Expression levels of estrogen, progesterone, and human epidermal receptors were showing insignificant difference among IL17 expression categories, P values 0.678, 0.623, and 0.361, respectively.

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