Study of anaemia in pregnancy and low birth weight in fluoride endemic area of Western Rajasthan: a cohort study

拉贾斯坦邦西部氟化物流行区妊娠期贫血和低出生体重儿研究:一项队列研究

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作者:Pankaj Bhardwaj, Neha Mantri, Nitin Kumar Joshi, Praveen Suthar, Praveen Sharma, Purvi Purohit, Pratibha Singh, Shashank Shekhar, Shweta Khandelwal, Giribabu Dandabathula, Pankaja Ravi Raghav, Nikky Ramawat, Sanjeev Jain, Manoj Patil, Abhay Gaidhane, Zahiruddin Quazi Syed, Deepak Saxena

Background

Fluoride is a noxious element known to destroy gastrointestinal mucosa, leading to erythrocytes' destruction and causing anaemia. The birth weight of newborn babies is a significant indicator of a child's vulnerability to the risk of childhood diseases and chances of existence.

Conclusions

Thus, in fluoride endemic areas, other factors should be included besides iron and folic acid supplementation for improving anaemia in pregnant women. This calls for assessing the effectiveness of de-fluoridation activities along with the area's most common indigenous food practices.

Methods

This prospective cohort study was planned to find linkages between fluorosis and the low-birth weight of newborn babies with anaemic mothers. Antenatal mothers until the 20th week of gestation were followed up till delivery in the Antenatal Clinic of a District Hospital in one of the known fluoride-endemic districts (Nagaur) and the other not-so-endemic district (Jodhpur) of Western Rajasthan.

Results

Around 19% of the newborn in Jodhpur and around 22% in Nagaur had low birth weight. Mean fluoride values in water samples were measured to be 0.57 (range from 0.0 to 2.7 PPM) in Jodhpur and 0.7 (range from 0.0 to 3.4 PPM) in Nagaur. Conclusions: Thus, in fluoride endemic areas, other factors should be included besides iron and folic acid supplementation for improving anaemia in pregnant women. This calls for assessing the effectiveness of de-fluoridation activities along with the area's most common indigenous food practices.

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