Abstract
Infective endocarditis (IE), an infection of the endocardial surface of the heart, is a severe condition frequently seen in intravenous drug users (IVDU), primarily driven by Staphylococcus aureus. This case study examines the intricate clinical, ethical, and multidisciplinary challenges in managing a 48-year-old female with a history of IVDU, who presented with IE and multisystem complications. Initial evaluation revealed systemic septicemia with disseminated intravascular coagulation, septic emboli, and significant tricuspid valve involvement. Comprehensive management included tailored antibiotic therapy, infectious disease consultation, and palliative care integration, complicated by newly diagnosed HIV, emotional distress, and chronic pain. This report highlights the unique pathophysiology of IE in IVDU, driven by endothelial trauma and microbial colonization, often affecting the tricuspid valve. Ethical dilemmas arose when the patient, fully informed of her prognosis, elected to discontinue treatment and transition to hospice care, creating tension between respecting autonomy and ensuring beneficence. These challenges necessitated multidisciplinary collaboration to balance medical interventions with patient preferences. The case underscores the critical importance of prompt diagnosis, ethical sensitivity, and patient-centered care in managing IE in high-risk populations. It advocates for compassionate communication and respect for patient autonomy while navigating complex clinical and ethical decisions.