Abstract
Giant lipomas, rare benign tumours composed of mature adipose tissue, represent only 1% of all lipomas, typically exceeding 10 cm in diameter or weighing over 1000 g. These tumours can cause nerve compression, discomfort, or functional impairment, necessitating surgical excision. We report a 52-year-old male with a giant intramuscular lipoma in the periscapular region, initially identified following significant weight loss after bariatric surgery. Clinical evaluation revealed a 15 × 20 cm mass, confirmed via computed tomography (CT) scan. Surgical excision was performed, followed by histopathological analysis, which confirmed a benign lipoma. Postoperative management was complicated by seroma formation, requiring drainage. This case underscores the importance of early diagnosis, imaging, and appropriate surgical management for large lipomas to prevent complications and recurrence while ensuring optimal cosmetic outcomes.