Abstract
Ganglioneuromas (GN) are tumours of ectodermal origin, derived from the neural crest cells. Appendiceal GN are extremely rare, with only eight contemporary case reports in the literature. Being benign and indolent, the necessity of resection for GNs is often debated. However, obtaining tissue to confirm the diagnosis can be challenging, frequently leading to surgical resection. We present a case of an 85-year-old male with an enlarging appendiceal nodule diagnosed endoscopically. Further investigation with computed tomography (CT) scan failed to define the pathology. A laparoscopic appendicectomy was performed, which confirmed the diagnosis of appendiceal GN.