Deoxygenative Cyanofunctionalization of Aldehydes and Ketones Enabled by Electrochemical Reduction

电化学还原法实现醛酮的脱氧氰基官能化

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Abstract

The deoxygenative difunctionalization of carbonyls converts readily available carbonyl compounds into value-added gem-difunctionalized building blocks. We report an electrochemical carbonyl umpolung approach for the deoxygenative cyanofunctionalization of aldehydes and ketones, affording various α-functionalized nitriles. Further derivatization of these products provides a versatile and modular platform for geminal disubstitution of carbonyl oxygens.

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