Conclusions
Our studies show that a bolus of LPS results in decreased FGF21 levels 4 h from exposure.
Objective
To investigate circulating levels of FGF21 after lipopolysaccharide (LPS) infusion. Design: Two randomized, single-blinded, placebo-controlled crossover trials were used. Setting: The studies were performed at a university hospital clinical research center. Patients and interventions: Study 1 (LPS bolus): Eight young, healthy, lean males were investigated two times: (1) after isotonic saline injection and (2) after LPS injection (bolus of 1 ng/kg). Each study day lasted 4 h. Study 2 (continuous LPS infusion): Eight, healthy males were investigated two times: (1) during continuously isotonic saline infusion and (2) during continuous LPS infusion (0.06 ng/kg/h). Each study day lasted 4 h. Circulating FGF21 levels were quantified every second hour by an immunoassay.
Results
A LPS bolus resulted in a late suppression (t = 240 min) of serum FGF21 (P = 0.035). Continuous LPS infusion revealed no significant effects on FGF21 levels (P = 0.82). Conclusions: Our studies show that a bolus of LPS results in decreased FGF21 levels 4 h from exposure.