Abstract
RATIONALE: Pheochromocytomas typically arise in the adrenal medulla, whereas ectopic pheochromocytomas/paragangliomas commonly occur near the abdominal aorta, bladder, mediastinum, and head. Diaphragmatic pheochromocytomas are exceedingly rare, and there is limited surgical experience with their treatment. PATIENT CONCERNS: In Case A, the subject is a 45-year-old male, while in Case B, the subject is a 59-year-old female. Both patients present with a history of paroxysmal hypertension. Computed tomography imaging revealed the presence of diaphragmatic tumors in both patients. The tumor in Case A was observed in the left diaphragm, while the tumor in Case B was located in the right diaphragm. DIAGNOSES: Two patients were diagnosed with diaphragmatic pheochromocytoma on the basis of disease progression, imaging, endocrinological assessment and postoperative histopathological examination. INTERVENTION: Both patients received the same standardized preoperative preparation, which included hypotensive therapy and intravenous rehydration. Subsequently, Case A underwent a transabdominal robotic laparoscopic surgical resection, while Case B underwent a transthoracic thoracoscopic surgical resection. OUTCOMES: Both patients demonstrated a favorable recovery trajectory and exhibited stable blood pressure at the 3-month follow-up. LESSONS: This report serves to remind the reader that the transthoracic approach to diaphragmatic pheochromocytoma may prove to be more advantageous than the transperitoneal approach. Additionally, precise preoperative localization of the tumor and careful intraoperative monitoring and assessment are imperative to achieve favorable outcomes.