Asymmetric Syntheses of L,L- and L,D-di-myo-inositol-1,1'-phosphate and their behavior as stabilizers of enzyme activity at extreme temperatures

The big "DIP"per: The preparation of both l,l-DIP and l,d-DIP (see structures) involves a complex case of double asymmetric induction in the key step of the synthesis. The differential ability of each isomer to contribute to thermoprotection in the context of a key enzyme has been assessed and both isomers of DIP are shown to possess biological activity.