Total syntheses of heimiol A, hopeahainol D, and constrained analogues

heimiol A、hopeahainol D 及其类似物的全合成

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Abstract

[Image: see text] IDSI TO THE RESCUE: Use of a carefully designed cascade process empowered by the unique iodonium-reagent IDSI [(Et(2)SI)(2)Cl•SbCl(6)] provided the means to construct the entire [3.2.2]-bicyclic core of both targets in a single, stereocontrolled operation. Use of strain energies assisted in the completion of the natural products, with the overall strategy proving applicable as well to the preparation of a number of unique [3.2.1]-dimeric and highly strained resveratrol-based compounds.

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