Abstract
Paraquat (PQ) is a non-selective contact herbicide, and acute PQ poisoning has a high mortality. The aim of the present study is to evaluate the prognostic value of hematological parameters in patients with acute PQ poisoning. We retrospectively reviewed the records of patients with acute PQ poisoning from January 2010 to December 2015 at the First Affiliated Hospital, Anhui Medical University (Hefei, China). A total of 202 patients were included in the study, and the 30-day mortality was 51.98%. Leukocyte, neutrophil counts and neutrophil-lymphocyte ratio (NLR) were significantly higher in non-survivors than in survivors. In the receiver operating characteristic (ROC) curve analysis, the NLR had an area of 0.916(95%CI, 0.877-0.954) and the optimal cut-off value was 10.57 (sensitivity, 86.70%; specificity, 83.51%; Youden's index, 0.702). The leukocyte counts had an area of 0.849(95%CI, 0.796-0.902) and the optimal cut-off value was 13.15 × 10(3)/mm(3) (sensitivity, 77.10%; specificity, 83.50%; Youden's index, 0.606). The neutrophil counts had an area of 0.878(95%CI, 0.830-0.925) and the optimal cut-off value was 10.10 × 10(3)/mm(3) (sensitivity, 83.80%; specificity, 79.38%; Youden's index, 0.632). NLR, leukocyte and neutrophil counts are associated with the 30-day mortality, which may be useful and simple parameters in predicting the prognosis of PQ poisoning.