Induction of humoral and cell-mediated immunity to the NS1 protein of TBEV with recombinant Influenza virus and MVA affords partial protection against lethal TBEV infection in mice

重组流感病毒和 MVA 诱导针对 TBEV NS1 蛋白的体液和细胞介导免疫，可为小鼠提供针对致命 TBEV 感染的部分保护

阅读：5
作者：Jana Beicht, Mareike Kubinski, Isabel Zdora, Christina Puff, Jeannine Biermann, Thomas Gerlach, Wolfgang Baumgärtner, Gerd Sutter, Albert D M E Osterhaus, Chittappen Kandiyil Prajeeth, Guus F Rimmelzwaan
期刊：Frontiers in Immunology影响因子：5.700
时间：2023起止号：2023 Jul 7:14:1177324.
doi：10.3389/fimmu.2023.1177324研究方向： 免疫
疾病类型： 流感细胞类型： 其它细胞

Discussion

This supports the inclusion of NS1 as a vaccine component in next generation TBEV vaccines.

Methods

Therefore, immunogenicity and protective efficacy of TBEV NS1 expressed by neuraminidase (NA)-deficient Influenza A virus (IAV) or Modified Vaccinia virus Ankara (MVA) vectors were investigated in this study.

Results

With these recombinant viral vectors TBEV NS1-specific antibody and T cell responses were induced. Upon heterologous prime/boost regimens partial protection against lethal TBEV challenge infection was afforded in mice.

特别声明

1、本页面内容包含部分的内容是基于公开信息的合理引用；引用内容仅为补充信息，不代表本站立场。

2、若认为本页面引用内容涉及侵权，请及时与本站联系，我们将第一时间处理。

3、其他媒体/个人如需使用本页面原创内容，需注明“来源：[生知库]”并获得授权；使用引用内容的，需自行联系原作者获得许可。

4、投稿及合作请联系：info@biocloudy.com。