Evaluation of Dose Dependent Maternal Exposure to Bisphenol A on Thyroid Functions in Newborns

母亲剂量依赖性双酚 A 暴露对新生儿甲状腺功能的影响评估

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作者:Burcin Sanlidag, Ceyhun Dalkan, Osman Yetkin, Nerin N Bahçeciler

Conclusion

Although BPA has been shown to contaminate cord blood, no significant effect was detected on thyroid hormones, SPINA-GT, TSHI and sTSHI. Further investigations with larger study populations are warranted.

Methods

The study population included 88 newborns. The BPA levels, Thyroid stimulating hormone (TSH) and free thyroxine (fT4) levels of cord blood were measured. In addition, SPINA-GT (thyroid' incretory capasity), TSH Index (TSHI), standardized TSHI (sTSHI) were calculated and demographic characteristics of participants were noted.

Results

The mean of cord blood BPA was 4.934 ± 2.33 ng/mL. When evaluated according to quantiles of BPA, no association was found between BPA and thyroid hormone levels, as well as, SPINA-GT, TSHI, sTSHI in both genders.

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