Engineering of therapeutic polypeptides through chemical synthesis: early lessons from human parathyroid hormone and analogues

通过化学合成设计治疗性多肽:从人类甲状旁腺激素及其类似物中吸取的早期经验

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作者:Suwei Dong, Shiying Shang, Jianfeng Li, Zhongping Tan, Thomas Dean, Akira Maeda, Thomas J Gardella, Samuel J Danishefsky

Abstract

Application of chemical synthesis to gain access to high purity hPTH as well as more stable analogues was accomplished through a menu of extended NCL followed by metal free dethiylation.

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