Vasoactive Intestinal Peptide Derived From Liver Mesenchymal Cells Mediates Tight Junction Assembly in Mouse Intrahepatic Bile Ducts

源自肝间充质细胞的血管活性肠肽介导小鼠肝内胆管中的紧密连接组装

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作者：Ayako Sato,Sei Kakinuma,Masato Miyoshi,Akihide Kamiya,Tomoyuki Tsunoda,Shun Kaneko,Jun Tsuchiya,Taro Shimizu,Eiko Takeichi,Sayuri Nitta,Fukiko Kawai-Kitahata,Miyako Murakawa,Yasuhiro Itsui,Mina Nakagawa,Seishin Azuma,Naohiko Koshikawa,Motoharu Seiki,Hiromitsu Nakauchi,Yasuhiro Asah
期刊：Hepatology Communications影响因子：5.600
时间：2019起止号：2019 Dec 24;4(2):235-254.
doi：10.1002/hep4.1459研究方向： 免疫、细胞生物学
细胞类型： 其它细胞

Conclusion

VIP is produced by periportal mesenchymal cells during the perinatal stage. It supports bile duct development by establishing tight junctions and up-regulating ion/water transporters in cholangiocytes. VIP contributes to prompt recovery from cholestatic damage through the establishment of tight junctions in the bile ducts.

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