Abstract
Rhinocerebral mucormycosis, an invasive fungal infection caused by Mucorales species, typically involves the paranasal sinuses, orbits, and central nervous system. Known for its aggressive nature, the infection often leads to severe complications and a high risk of mortality. Common risk factors include uncontrolled diabetes mellitus, immunosuppression, prolonged use of glucocorticoids, and hematologic malignancies. Patients with hematologic malignancies are particularly susceptible to this infection due to compromised immune function. This case report details an instance of acute lymphoblastic leukemia complicated by naso-ocular encephalomycosis, providing a comprehensive overview of its clinical presentation, diagnostic approach, therapeutic management, and prognosis. Additionally, preventive measures and early diagnosis are important in patients with hematologic malignancies.