Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate Cancer

主转录因子重编程释放选择性翻译，促进致命前列腺癌的去势抵抗和免疫逃避

阅读：7

作者：Sandra Santasusagna #, Shijia Zhu #, Vijayakumar Jawalagatti #, Marc Carceles-Cordon, Adam Ertel, Saioa Garcia-Longarte, Won-Min Song, Naoto Fujiwara, Peiyao Li, Isabel Mendizabal, Daniel P Petrylak, William Kevin Kelly, E Premkumar Reddy, Liguo Wang, Matthew J Schiewer, Amaia Lujambio, Jeffrey Karn

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2023

起止号：

2023 Dec 12;13(12):2584-2609.

doi：

10.1158/2159-8290.CD-23-0306

研究方向：

信号转导、肿瘤

疾病类型：

前列腺癌

信号通路：

Translational Control

Significance

Our study shows that specialized eIF3B-dependent translation of specific mRNAs released upon downregulation of the master transcription factor MITF confers castration resistance and immune evasion in lethal prostate cancer. Pharmacologic targeting of this mechanism delays castration resistance and increases immune-checkpoint efficacy. This article is featured in Selected Articles from This Issue, p. 2489.

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