PHD2 enzyme is an intracellular manganese sensor that initiates the homeostatic response against elevated manganese
PHD2 酶是一种细胞内锰传感器，可启动针对高锰水平的稳态反应
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作者：Kerem C Gurol, Thomas Jursa, Eun Jeong Cho, Walter Fast, Kevin N Dalby, Donald R Smith, Somshuvra Mukhopadhyay
Results
1) define a fundamental Mn sensing mechanism for controlling Mn homeostasis-elevated Mn inhibits PHD2, which functions as a Mn sensor, by outcompeting its catalytic Fe, and PHD2 inhibition activates HIF signaling to up-regulate SLC30A10; and 2) identify a unique mode of metal sensing that may have wide applicability.
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