Abstract
The regulation of end-of-life decisions has been the subject of intense debate for years, marked by the challenge of reconciling two fundamental ethical principles: preservation of life and individual self-determination. From a legal perspective, numerous court rulings have outlined an evolving framework, highlighting the difficulty of establishing a regulatory approach that balances constitutional rights with ethical values. This study examines key Italian judicial decisions, with a particular focus on recent Constitutional Court rulings regarding end-of-life issues, and discusses the underlying ethical and humanistic perspectives. We aim to explore the key ethical and legal issues arising in the context of end-of-life regulation. Judicial developments demonstrate an increasing recognition of individual self-determination in accessing assisted suicide despite persisting ongoing ambiguities and regulatory gaps. The end-of-life debate underscores the urgency of moving beyond abstract and schematic approaches, favoring a perspective that integrates multidisciplinary expertise and human sensitivity. Ensuring effective access to palliative care and comprehensive social and healthcare systems is essential to alleviate suffering and provide genuine alternatives to assisted suicide.