Abstract
Examining the history of vaccination in the Civil War reveals lessons about why citizens resisted vaccination and how physicians tried to respond to the problems associated with combating epidemic diseases like smallpox. The Confederate government and physicians failed to effectively advocate to the public and collect information in an organized manner, and they suffered failures in getting enough citizens and soldiers vaccinated. Some Confederate physicians like Joseph Jones studied vaccination, but this came after the war, and the Confederate government failed to embrace and combat vaccine hesitancy. In some cases, more radical political elements tried to control the conversation through newspaper articles. Criticisms of vaccination likely continued to haunt the perceptions of vaccination in the Southern United States.