Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans

HNF4α 的细胞定位与人类晚期肝功能衰竭相关

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作者:Rodrigo M Florentino, Nicolas A Fraunhoffer, Kazutoyo Morita, Kazuki Takeishi, Alina Ostrowska, Abhinav Achreja, Olamide Animasahun, Nils Haep, Shohrat Arazov, Nandini Agarwal, Alexandra Collin de l'Hortet, Jorge Guzman-Lepe, Edgar N Tafaleng, Amitava Mukherjee, Kris Troy, Swati Banerjee, Shirish Pa

Conclusion

These results suggest that the alterations in the cMET-AKT pathway directly correlate with HNF4α localization and level of hepatocyte dysfunction. This study suggests that manipulation of HNF4α and pathways involved in HNF4α posttranslational modification may restore hepatocyte function in patients with terminal liver failure.

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