Anticancer-active 3,4-diarylthiolated maleimides synthesis via three-component radical diarylthiolation

通过三组分自由基二芳基硫代化反应合成具有抗癌活性的3,4-二芳基硫代马来酰亚胺

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Abstract

Herein, we report an efficient and simple copper-catalyzed oxidative diarylthiolation of maleimides with sulfur powder and aryl boronic acids, in which S powder was used as a substrate and internal oxidant. The corresponding double C-S bonds coupling products were obtained in moderate to high yields under a simple catalytic system. Mechanistic studies indicated that copper-catalyzed radical thiolation of aryl boronic acids with S powder, and the resulting arylthiyl underwent radical addition with double bonds of maleimides.

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