Abstract
This systematic review analyzes the use of artificial intelligence (AI) tools to improve medication adherence in patients with chronic non-communicable diseases, with a specific focus on their implementation in pharmaceutical care. Medication non-adherence remains a major barrier to effective chronic disease management, contributing to poor clinical outcomes and rising healthcare costs. AI offers promising, data-driven approaches to address this challenge through tools such as conversational agents, mobile applications, smart devices, and adherence classifiers. These tools enhance patient monitoring, education, and engagement, enabling personalized interventions to promote consistent medication use. The 26 included studies were evaluated based on their methodology, type of AI tool, healthcare setting, and reported impact on adherence outcomes. Most reported improvements in adherence, though variation in assessment methods limits comparability. Ethical, legal, and accessibility issues remain key challenges to wider adoption. Overall, AI represents a valuable and emerging strategy for supporting adherence and optimizing pharmaceutical care in chronic disease management.