Serum osteoprotegerin level in hemodialysis patients using low-flux reused dialyzer in relation to atherosclerosis

低通量重复使用透析器血液透析患者血清骨保护素水平与动脉粥样硬化的关系

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作者:Tung Do Van, Tuan Nguyen Minh, Quyen Dao Bui Quy, Toan Pham Quoc, Toan Nguyen Duy, Kien Nguyen Trung, Hoang Nguyen Cong, Lan Le Thi Huong, Huong Bui Thi Thu, Tien Tran Viet, Quyet Do, Mao Can Van, Thang Le Viet

Aims

To assess the relation of high serum OPG level and carotid atherosclerosis in maintenance hemodialysis (MHD) patients using low-flux reused dialyzer. Materials and

Conclusions

In this study, serum OPG had a good predicting value for atherosclerosis in MHD patients using low-flux reused dialyzer.

Methods

We examined 209 MHD patients with and without carotid atherosclerosis (83 patients and 126 patients) to establish the relation between OPG and atherosclerosis.

Results

The proportion of carotid atherosclerosis was 39.7%. The median serum OPG level was 45.3 pmol/L. Serum OPG had a good predicting value for atherosclerosis in MHD patients using low-flux reused dialyzer (AUC = 0.934, p < 0.001, cutoff value = 43.35 pmol/L, Se = 81.3%, Sp = 90.9%). Conclusions: In this study, serum OPG had a good predicting value for atherosclerosis in MHD patients using low-flux reused dialyzer.

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