Conclusions
The present method was found to be precise, sensitive, and rapid to determine 26 PPPCPs including phthalates in river water samples using SPE-UHPLC-Q-Orbitrap-MS.
Results
The method was found to be linear in the concentration range of 1-125 ng/L with coefficient of determination lying in the range of 0.995-0.999. The method achieved limit of quantification in the range of 0.41-1.72 ng/L, and method recovery measured at three different concentrations was found to be in the range of 75-115%. Intra- and interday precision expressed as percent relative standard deviation was found to be <15%. Matrix effect was found to be in the range of 83.5-109.79%. The matrix match calibration was used for quantification of PPPCPs in river water sample. The method performance was evaluated by analyzing real samples collected from Ganga River, and the concentrations of 21 analytes were found to be in the range of 0.76-9.49 ng/L for pharmaceuticals, 1.49-8.67 ng/L for phthalates, and 0.9-7.58 ng/L for personal care products. Conclusions: The present method was found to be precise, sensitive, and rapid to determine 26 PPPCPs including phthalates in river water samples using SPE-UHPLC-Q-Orbitrap-MS.