The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung Adenocarcinoma

早期肺腺癌中 B 细胞和浆细胞的单细胞免疫基因组学图谱

阅读：13

作者：Dapeng Hao #, Guangchun Han #, Ansam Sinjab #, Lorena Isabel Gomez-Bolanos, Rossana Lazcano, Alejandra Serrano, Sharia D Hernandez, Enyu Dai, Xuanye Cao, Jian Hu, Minghao Dang, Ruiping Wang, Yanshuo Chu, Xingzhi Song, Jianhua Zhang, Edwin R Parra, Jennifer A Wargo, Stephen G Swisher, Tina Cascone, B

期刊：

Cancer Discovery

影响因子：

29.700

时间：

2022

起止号：

2022 Nov 2;12(11):2626-2645.

doi：

10.1158/2159-8290.CD-21-1658

研究方向：

免疫

疾病类型：

肺癌

细胞类型：

B细胞

Significance

While TIBs are highly enriched in LUADs, they are poorly characterized. This study provides a much-needed understanding of the transcriptional, clonotypic states and phenotypes of TIBs, unraveling their potential roles in the immunopathology of early-stage LUADs and constituting a road map for the development of TIB-targeted immunotherapies for the treatment of this morbid malignancy. This article is highlighted in the In This Issue feature, p. 2483.

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