Abstract
Background: The aim of this study was to assess the incidence, outcomes, and risk factors associated with thrombocytopenia following TAVI according to a corrected platelet count (CPC), to avoid the bias of hemodilution/concentration. Methods: We analyzed patients who underwent TAVI in our center between 2009 and 2018. The study population were divided into three groups: none (NT), mild (MT), and severe (ST) postoperative thrombocytopenia. Primary outcomes were bleedings, length of hospital stay, and mortality. A multivariate logistic regression was performed to assess risk factors for ST. Results: A total of 907 patients were included in the analysis. MT was observed in 28.1% and ST in 2.6% of all patients. The following clinical outcomes were recorded: incidence of life-threatening and major bleeding (NT = 14.2%, MT = 20.8%, ST = 58.3%), the median length of hospital stay (NT = 8, MT = 10, ST = 14 days), in-hospital mortality (NT = 3.9%, MT = 6.3%, ST = 16.7%), and the overall significance in comparison with NT (p < 0.05). The logistic regression showed ST was associated with preoperative CPC, transapical access, diabetes mellitus, and the critical preoperative state. Conclusions: Worse clinical outcomes are associated with both MT and ST after TAVI. In particular, ST is associated with higher in-hospital and 30-day mortality. Management of modifiable baseline and procedural variables may improve this outcome.