The Prognostic Value of Eosinophil Recovery in COVID-19: A Multicentre, Retrospective Cohort Study on Patients Hospitalised in Spanish Hospitals

嗜酸性粒细胞恢复对 COVID-19 的预后价值:一项针对西班牙医院住院患者的多中心回顾性队列研究

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作者:María Mateos González, Elena Sierra Gonzalo, Irene Casado Lopez, Francisco Arnalich Fernández, José Luis Beato Pérez, Daniel Monge Monge, Juan Antonio Vargas Núñez, Rosa García Fenoll, Carmen Suárez Fernández, Santiago Jesús Freire Castro, Manuel Mendez Bailon, Isabel Perales Fraile, Manuel Madrazo,

Conclusion

Eosinophil recovery in patients with COVID-19 who required hospitalisation had an independent prognostic value for all-cause mortality and a milder course.

Results

An increase in the eosinophil count on the seventh day of hospitalisation was associated with a better prognosis, including lower mortality rates (5.2% vs. 22.6% in non-recoverers, OR 0.234; 95% CI, 0.154 to 0.354) and lower complication rates, especially regarding the development of acute respiratory distress syndrome (8% vs. 20.1%, p = 0.000) and ICU admission (5.4% vs. 10.8%, p = 0.000). Lymphocyte recovery was found to have no effect on prognosis. Treatment with inhaled or systemic glucocorticoids was not found to be a confounding factor.

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