Abstract
Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic arboviral disease caused by a virus of Bunyaviridae family, genus Orthonairovirus and transmitted by tick bite. The virus causes subclinical infection in animals and severe viral hemorrhagic disease, with a fatality rate of 10-40% in humans.Between January and February 2020, eighteen human cases of CCHF including nine deaths, were recorded in the health district of the Mopti region in Mali. The present study carried out to determine CCHF seroposivity in cattle and sheep and to identify the risk factors associated with the presence of antibodies in cattle and sheep in the Mopti region. A cross-sectional survey was conducted on a total of 200 cattle and sheep sampled in the localities of Konna and Mopti urban area. The double antigen sandwich ELISA technique allowed to establish a true overall seropositivity of 43.8% (95% CI: 36.9 - 50.6) including seropositivity of 40% (95 CI: 30.4-49.6) in Konna and 45.5% (95% CI: 35.2-54.8) in Sevare. According to species, seropositivity was 58.6% (95% CI: 48.3-67.7) in cattle and 27% (95% CI: 18.3-35.7) in sheep. Biostatistical analysis showed that cattle (OR=3.77; 95% CI: 2.07-6.87) were more likely to be seropositive compared than in sheep. This study demonstrates the circulation of virus in animals and the need to conduct joint actions according to the "One Health" approach for the control of this zoonosis.