Abstract
Hybrid cysts originate from more than two components of the pilosebaceous unit. The pathogenesis of this cystic lesion remains unclear. Most of the investigated cases have scalp and face predilection. The lesion is predominantly observed in females. We present a case of a 69-year-old woman with a painless cutaneous nodule measuring 0.7 cm on the right calf. After a surgical excision, the histological investigation showed that the normal epidermis was elevated by a deeply encapsulated intradermal cyst, which was lined by two distinct histological types of epithelium with an abrupt transition between them. One-half of the cystic surface consisted of a keratinizing squamous layer with a granular layer and keratin lamellae, while the other half was lined by epithelium showing pilomatricial differentiation. Finally, an extremely rare diagnosis was set of a hybrid cyst.