Genome-wide association and linkage analysis of quantitative traits: comparison of likelihood-ratio test and conditional score statistic

全基因组关联和连锁分析在数量性状中的应用:似然比检验与条件得分统计量的比较

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Abstract

Over the past decade, genetic analysis has shifted from linkage studies, which identify broad regions containing putative trait loci, to genome-wide association studies, which detect the association of a marker with a specific phenotype. Because linkage and association analysis provide complementary information, developing a method to combine these analyses may increase the power to detect a true association. In this paper we compare a linkage score and association score test as well as a newly proposed combination of these two scores with traditional linkage and association methods.

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