Abstract
CONTEXT: Vitamin E, a well-known antioxidant with numerous positive effects on human health, encompasses tocotrienol-rich fraction (TRF), a natural variant abundant in palm oil. OBJECTIVE: This systematic review analyzed findings from randomized controlled trials published until 2022 to evaluate the health impacts of palm TRF. DATA SOURCES: A literature search was performed in Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, OVID Medline, SCOPUS, and Web of Science from inception until December 2022. Thirty studies involving 2646 patients, including both healthy individuals and those with underlying conditions, were identified. RESULTS: This review shows palm TRF to be a promising natural supplement against inflammation and lipid peroxidation and that can significantly enhance overall health. Additionally, the study underscores the necessity for further research to ascertain the optimal dosage, formulation, and duration of supplementation, maximizing the potential health advantages. CONCLUSION: This systematic review provides evidence supporting the health benefits associated with palm TRF. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42020204070.